DRviaSPCN: Drug Repurposing in Cancer via a Subpathway Crosstalk Network
A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.
||R (≥ 3.6)
||GSVA, clusterProfiler, graphics, igraph, pheatmap, stats
||rmarkdown, knitr, DT
||Junwei Han [aut, cre, cph],
Jiashuo Wu [aut]
||Junwei Han <hanjunwei1981 at 163.com>
||GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
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