tLagInterim: Interim Monitoring of Clinical Trials with Time-Lagged Outcome

Implements inverse and augmented inverse probability weighted estimators for common treatment effect parameters at an interim analysis with time-lagged outcome that may not be available for all enrolled subjects. Produces estimators, standard errors, and information that can be used to compute stopping boundaries using software that assumes that the estimators/test statistics have independent increments. Tsiatis, A. A. and Davidian, M., (2022) <doi:10.48550/arXiv.2204.10739> .

Version: 1.0
Depends: R (≥ 3.5.0), survival
Imports: R.utils
Published: 2022-08-17
DOI: 10.32614/CRAN.package.tLagInterim
Author: Shannon T. Holloway [aut, cre], Marie Davidian [aut], Anastasios Tsiatis [aut]
Maintainer: Shannon T. Holloway <shannon.t.holloway at>
License: GPL-2
NeedsCompilation: no
CRAN checks: tLagInterim results


Reference manual: tLagInterim.pdf


Package source: tLagInterim_1.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): tLagInterim_1.0.tgz, r-oldrel (arm64): tLagInterim_1.0.tgz, r-release (x86_64): tLagInterim_1.0.tgz, r-oldrel (x86_64): tLagInterim_1.0.tgz


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